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Effect of soy sterols on cholesterol synthesis in the rat
Author(s) -
FishlerMates Z.,
Budowski P.,
Pinsky A.
Publication year - 1973
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533237
Subject(s) - clinical chemistry , lipidology , cholesterol , medicine , chemistry , endocrinology , sterol , plant sterols , cholesterol synthesis , food science , biochemistry , biology , enzyme , reductase
Soy sterols increased the incorporation of acetate into cholesterol by rat liver slices and prevented the depression of cholesterogenesis caused by dietary cholesterol. Acetate incorporation into cholesterol by intestinal slices was not affected by soy sterols but was decreased by cholesterol. The results with liver slices agree with the view that soy sterols, by interfering with the intestinal absorption of cholesterol, prevent the feedback inhibition of hepatic cholesterogenesis.