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Jimpy mouse: In vitro studies of brain sphingolipid biosynthesis
Author(s) -
Morell Pierre,
CostantinoCeccarini Elvira
Publication year - 1972
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533227
Subject(s) - sphingolipid , lipidology , in vitro , clinical chemistry , biosynthesis , microsome , biochemistry , chemistry , neurochemistry , biology , microbiology and biotechnology , neuroscience , neurology , enzyme
Microsomal preparations from brains of Jimpy mice are able to synthesize only 10–20% as much galactosylceramide as preparations from control littermates. Synthesis of glucosylceramide and ketodihydrosphingosine is only slightly impaired.
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