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The hypolipidemic effect of calcium‐containing compounds and vitamin D 2 in the rat
Author(s) -
Fleischman Alan I.,
Bierenbaum Marvin L.,
Lenz Paul H.
Publication year - 1972
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533226
Subject(s) - calcium , chemistry , medicine , triglyceride , endocrinology , cholesterol , calcium carbonate , hyperlipidemia , vitamin , lipidology , clinical chemistry , phytosterol , feces , magnesium , sterol , biochemistry , biology , paleontology , organic chemistry , diabetes mellitus
Abstract Two per cent dietary calcium carbonate alone (Group 1), in combination with vitamin D 2 (Group 2) or oyster shell calcium with vitamin D 2 (Group 3), was added to an atherogenic diet containing 20% fat and 2% cholesterol and fed to adult male Holtzman strain rats to evaluate the hypolipidemic effects of these supplements. A control group received the same diet, but the calcium was replaced by sand. After 21 days the serum cholesterol concentrations were lower by 35, 27 and 22%, respectively, in experimental groups 1, 2 and 3, compared to the controls. Serum triglyceride concentrations were lower by 10% in experimental groups 1, 2 and 3, compared to the controls. Serum triglyceride concentrations were lower by 10% in groups 1 and 2, and 17% in group 3. Concomitant with these decreases in serum lipids, there were increases in fecal 3‐β‐hydroxy‐5‐ene sterol, total glyceride and free fatty acid excretion. Serum calcium was elevated in the rats fed diets containing calcium when compared with the controls, whereas serum magnesium was depressed in thesy animals. Less calcium was excreted in the feces of rats fed calcium carbonate in combination with vitamin D than in those fed calcium carbonate. The results indicate a possible means of simultaneously treating both calcium deficiency and hyperlipidemia with a single agent.