Synthesis of 1,2 dilinoleoyl and 1,2 dipalmitoyl sn ‐3‐glycerophosphorylcholine | Zendy

Gordon D. T. | Zendy; Jensen R. G. | Zendy

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Synthesis of 1,2 dilinoleoyl and 1,2 dipalmitoyl sn ‐3‐glycerophosphorylcholine

Author(s) -

Gordon D. T.,

Jensen R. G.

Publication year - 1972

Publication title -

lipids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.601

H-Index - 120

eISSN - 1558-9307

pISSN - 0024-4201

DOI - 10.1007/bf02533225

Subject(s) - chemistry , crystallization , potassium , chromatography , salt (chemistry) , nuclear chemistry , acetone , organic chemistry

The synthesis of 1,2 dilinoleoyl sn ‐3‐glycerophosphorylcholine (1,2‐18∶2‐ sn ‐3‐GPC) and 1,2 dipalmitoyl sn ‐3‐glycerophosphorylcholine (1,2‐16∶0‐ sn ‐3‐SPC) is described. Synthesis was accomplished by acylating free glycerophosphorylcholine (GPC) with the anhydride and potassium salt of the desired acid. Purification of 1,2‐16∶0‐ sn ‐3‐GPC was accomplished by crystallization, while purification of 1,2‐18∶2‐ sn ‐3‐GPC required the use of alumina column chromatography and then crystallization from acetone at −7C.

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