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Intracerebrally injected monohydroxy and other C 24 steroid acids as demyelinating agents in the guinea pig
Author(s) -
Mujtaba Naqvi S. H.,
Herndon B. L.,
Del Rosario L.,
Nicholas H. J.
Publication year - 1970
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533198
Subject(s) - lithocholic acid , chemistry , guinea pig , sodium , lipidology , clinical chemistry , chromatography , biochemistry , medicine , organic chemistry , bile acid
Sodium salts of lithocholic acid (3α‐hydroxy‐5β‐cholanoic acid), 5β‐cholanoic acid, Δ 5 ‐cholenoic acid and 3‐keto‐5β‐cholanoic acid injected intracerebrally into guinea pigs in doses of 1 mg or higher produced periventricular demyelination. 24‐ 14 C‐sodium lithocholate was rapidly released from the brain (only traces remained 2 hr after injection) if injected in quantities ranging from 2 μg to 5 mg. This rapid elimination is believed to account for the relatively high dose of lithocholate required for producing demyelination, and may also account for the limited demyelinating capacity of the other acids injected intracerebrally.