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The incorporation of 2‐aminoethylphosphonic acid into rat liver diacylglyceroaminoethylphosphonate
Author(s) -
Curley Jean M.,
Henderson Thomas O.
Publication year - 1972
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533076
Subject(s) - phosphatidylethanolamine , lipidology , chemistry , clinical chemistry , diacylglycerol kinase , hydrolysis , phosphonate , adipose tissue , biochemistry , chromatography , medicine , enzyme , phospholipid , phosphatidylcholine , protein kinase c , membrane
Rats intravenously administered ( 14 C) 2‐aminoethylphosphonic acid (AEP) incorporated ca. 16% of the total injected compound into liver lipids. Thin layer chromatography and selective chemical and enzymatic hydrolysis of the labeled lipids demonstrated that essentially all of the radioactivity was in one compound, diacylglycerol‐AEP, the phosphonate analog of phosphatidylethanolamine. Lipids from kidneys, heart, skeletal muscle, adipose, pancreas and brain were examined and found to contain less than 2% collectively of the total injected radioactivity. The residues from the tissues contained ca. 3.2% of the total injected ( 14 C) AEP.