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Protective effect of 3‐hydroxy‐3‐methylglutaric acid in alcohol‐induced lipemia
Author(s) -
Yousufzai S. Y. K.,
Siddiqi Majid,
Abdullah A. K.
Publication year - 1976
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02532897
Subject(s) - chemistry , postprandial , ethanol , nicotinic agonist , clinical chemistry , alcohol , ingestion , corn oil , endocrinology , medicine , lipidology , cholesterol , biochemistry , food science , insulin , receptor
Abstract Oral administration of 1 g of 3‐hydroxy‐3‐methylglutaric acid (HMG) before the ingestion of whiskey and a fatty meal markedly reduced the elevation of serum triglycerides, β‐lipoproteins, phospholipids, and cholesterol in man. In rats receiving an ethanol and corn oil mixture, HMG also inhibited the increase in postprandial serum and liver lipids. A comparative study of HMG and nicotinic acid in rats showed that, therapeutically, 50 mg MHG/kg body weight is equivalent to 200 mg nicotinic acid/kg body weight in offering almost total protection against lipemic effects of ethanol.