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Age‐related changes in the lipid metabolism of Fisher 344 rats
Author(s) -
Story Jon A.,
Tepper Shirley A.,
Kritchevsky David
Publication year - 1976
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02532876
Subject(s) - medicine , endocrinology , clinical chemistry , lipid metabolism , lipidology , triglyceride , cholesterol , metabolism , reductase , biology , ageing , age groups , biochemistry , enzyme , demography , sociology
Lipid metabolism of male Fisher 344 rats aged 2–24 months was studied. Serum and liver cholesterol levels did not display the age‐related gradual increase seen in other rat strains. An increase in the serum plus liver cholesterol pool from 2 to 6 months was followed by a plateau through 18 months and then another increase at 24 months of age. The triglyceride pool increased from 2 to 6 months and then remained unchanged through 24 months of age. Cholesterol synthesis from acetate decreased 50% between 2 and 9 months and fell only slightly through 24 months of age. Assay of 3‐hydroxy‐3‐methyl glutaryl Coenzyme A (HMG‐CoA) reductase showed a similar pattern but did not decrease further after 9 months of age. Cholesterol 7α hydroxylase activity was not significantly altered by age. These age‐ and strain‐related differences present an opportunity for a comparative study of the aging process using the parameters of lipid metabolism as indicators.