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Glycodihydrofusidate: Biliary excretion and its effect on biliary secretion of the rat
Author(s) -
Montet J. C.,
Montet A. M.,
Gerolami A.,
Amic J.,
Hauton J. C.
Publication year - 1976
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02532848
Subject(s) - lecithin , medicine , excretion , lipidology , clinical chemistry , cholesterol , chemistry , endogeny , endocrinology , secretion , bile duct , biochemistry , biology
Glycodihydrofusidate, which has the same detergent properties as bile salts, is excreted almost exclusively by the bile duct after intravenous injection in the rat. As with bile salts, it leads to a significant (P≤0.05) increase in excretion of lecithins and cholesterol (0.15 μmol lecithin and 0.026 μmol cholesterol per 1 μmol of glycodihydrofusidate excreted). In addition, this drug simultaneously inhibits excretion of both endogenous bile salts and bile pigments.