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Site of bile acid absorption in the rat
Author(s) -
Sklan D.,
Budowski P.,
Hurwitz S.
Publication year - 1976
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02532837
Subject(s) - jejunum , ileum , bile acid , cholic acid , absorption (acoustics) , small intestine , chemistry , medicine , biochemistry , materials science , composite material
Bile acid absorption was measured in the small intestine of the rat using 91 Y as a nonabsorbed reference substance. Some 50% of the secreted bile acids were absorbed in the proximal half of the small intestine. In situ incubations of ligated intestinal segments into which tauro( 14 C‐carbonyl)cholic acid was introduced confirmed the considerable uptake of bile acids in the jejunum. The in situ experiments indicated that serosal transport is the limiting stage of bile acid absorption in the jejunum but not in the ileum. Increasing bile acid concentrations in the in situ experiments did not affect the percentage disappearance of dose from the jejunum but reduced the percentage mucosal uptake in the ileum. It is concluded that, in the rat, the proximal small intestine is as important in the absorption of bile acids as the distal small intestine.

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