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Lipogenesis by intact hepatocytes from normal and diabetic rats
Author(s) -
Raghupathy E.,
Orthlieb C.,
Abraham S.
Publication year - 1975
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02532756
Subject(s) - lipogenesis , clinical chemistry , medicine , lipidology , endocrinology , hepatocyte , insulin , chemistry , hormone , diabetes mellitus , lipid metabolism , biology , biochemistry , in vitro
Intact hepatocytes isolated from livers of diabetic rats demonstrate the characteristic decreased lipogenic capacities as compared to normal. Administration of insulin to diabetic rats restores these capacities to near normal levels. The results emphasize the potential that the hepatocyte system has for the study of hormonal regulation of lipogenesis.