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Detection of lithocholic acid in multiple sclerosis brain tissue
Author(s) -
Mujtaba Naqvi S. H.,
Ramsey Robert B.,
Nicholas H. J.
Publication year - 1970
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02532752
Subject(s) - lithocholic acid , multiple sclerosis , lipidology , autopsy , human brain , pathology , clinical chemistry , coronal plane , medicine , chemistry , biology , anatomy , biochemistry , immunology , neuroscience , bile acid
By methods previously employed for detecting lithocholic acid in brains of guinea pigs afflicted with experimental allergic encephalitis, the same acid was detected in a coronal specimen of human brain obtained on autopsy of a multiple sclerosis patient. The specimen contained several well‐defined demyelinated plaque areas. No lithocholic acid was detected in a somewhat larger coronal specimen of normal human brain.