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Enzymatic conversion of 5α‐cholesta‐7,14‐dien‐3β‐ol to 5α‐cholesta‐8,14‐dien‐3β‐ol
Author(s) -
Hsiung H. M.,
Spike T. E.,
Schroepfer G. J.
Publication year - 1975
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02532727
Subject(s) - incubation , clinical chemistry , enzyme , biosynthesis , lipidology , microsome , anaerobic exercise , chemistry , biochemistry , chromatography , biology , physiology
5α‐Cholesta‐7,14‐dien‐3β‐ol, previously shown to be efficiently converted to cholesterol upon incubation with rat liver homogenate preparations under aerobic conditions, has been studied as to its possible conversion to 5α‐cholesta‐8,14‐dien‐3β‐ol. Efficient conversion was observed upon incubation in the presence of washed microsomes of rat liver under anaerobic conditions. This observation is of importance in consideration of possible metabolic pathways in the biosynthesis of cholesterol.