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D‐galactosamine induced fatty liver: II. Analyses of hepatic lipid compositions
Author(s) -
Morita A.
Publication year - 1973
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02532711
Subject(s) - lysophosphatidylcholine , phospholipid , chemistry , triglyceride , lipidology , medicine , fatty acid , arachidonic acid , galactosamine , clinical chemistry , fatty liver , endocrinology , biochemistry , phosphatidylcholine , chromatography , cholesterol , biology , disease , membrane , glucosamine , enzyme
Female rats of the Wistar strain received six separate intraperitoneal injections of D‐galactosamine (250 mg/kg body wt per single injection). The rats were sacrificed 48 hr after the initial injection and the livers analyzed for their lipid compositions. A marked increase in the levels of total lipids and triglyceride with a pronounced decrease in phospholipid content in the liver was observed. However the percentage of individual phospholipid fractions obtained by thin layer chromatography showed no significant changes after D‐galactosamine administration, except for a slight increase in lysophosphatidylcholine. Fatty acid analyses of total lipids and phospholipids demonstrated an increase in the percentage of oleic and linoleic acids, with a decrease in the percentage of arachidonic acid after D‐galactosamine administration. In the triglyceride fraction, a slight increase in the percentage of myristic, palmitoleic and linolenic acids was observed.