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Slow exchange of erythrocyte and plasma phospholipids
Author(s) -
Calvert G. D.,
Scott P. J.
Publication year - 1974
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02532695
Subject(s) - phospholipid , phosphatidylcholine , clinical chemistry , phosphorus , chemistry , lipidology , biochemistry , metabolism , chromatography , organic chemistry , membrane
32 P‐Orthophosphate was injected intravenously into a pig, and the specific activities of serum phospholipids and phosphatidylcholine, serum and urine inorganic phosphorus, and erythrocyte phospholipids were followed for the next eight days. The specific activities of serum phospholipids, phosphatidylcholine, and inorganic phosphorus declined monoexponentially and were not significantly different from each other after the first day. These data imply that there are no large poorly labeled pools of inorganic phosphorus or phospholipids supplying serum phospholipid. Phospholipid metabolism is sufficiently rapid to obscure any immediate precursor product relationship. The specific activity of erthrocyte phospholipid rose slowly to a maximum on ca. the fourth day. The data were consistent with a precursor product relationship between serum phospholipids and part of the erythrocyte phospholipids.