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Lipid peroxidation in chronic ethanol treated rats: In vitro uncoupling of peroxidation from reduced nicotine adenosine dinucleotide phosphate oxidation
Author(s) -
Koes Mary,
Ward Tom,
Pennington Sam
Publication year - 1974
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02532616
Subject(s) - lipid peroxidation , nicotinamide adenine dinucleotide phosphate , chemistry , microsome , nicotinamide adenine dinucleotide , ethanol , biochemistry , alcohol dehydrogenase , nad+ kinase , in vitro , oxidase test , antioxidant , enzyme
Chronic ethanol treated rats were found to have enhanced ethanol metabolism and to metabolize ethanol in vivo in the presence of an inhibitor of alcohol dehydrogenase. In vitro studies of the hepatic microsomal system thought to the responsible for this activity showed it to be markedly induced. Lipid peroxidation also was enhanced in the ethanol treated animals. The lipid peroxidation was shown to be uncoupled from the microsomal nicotinamide adenine dinucleotide phosphate, reduced form, oxidase activity by a low concentration of azide.