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Changes in in vivo metabolism of bile acids in rat after treatment with phenobarbital
Author(s) -
Cronholm Tomas,
Einarsson Kurt,
Gustafsson JanÅke
Publication year - 1974
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02532607
Subject(s) - chenodeoxycholic acid , phenobarbital , cholic acid , chemistry , lipidology , in vivo , clinical chemistry , medicine , metabolism , endocrinology , bile acid , biochemistry , biology , microbiology and biotechnology
Abstract The influence of phenobarbital on pool size and turnover of bile acids in rats have been investigated by administration of [24‐ 14 C] cholic acid and tritium labeled chenodeoxycholic acid. Phenobarbital treated rats had a smaller cholic acid pool compared to control rats (6.08±2.09 mg and 23.60±7.66 mg, respectively). The pool size of chenodeoxycholic acid, plus its metabolites (α‐ and β‐muricholic acids), was of the same magnitude in the two groups of animals. Also the daily production of cholic acid was decreased in phenobarbital treated rats compared to control rats (2.12±0.46 mg and 7.24±1.66 mg, respectively). No significant difference was observed between the synthesis of chenodeoxycholic acid in the two groups of animals.