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Effects of ethyl p ‐chlorophenoxyisobutyrate on biliary secretion of bile acids, cholesterol and phosphatidyl choline
Author(s) -
Horning M. G.,
Hebert R. M.,
Roth R. J.,
Davis D. L.,
Horning E. C.,
Fischer E. P.,
Jordan G. L.
Publication year - 1972
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02532598
Subject(s) - chemistry , cholesterol , triglyceride , bile acid , medicine , phosphatidyl choline , chromatography , secretion , endocrinology , biochemistry , biology , phospholipid , membrane
The effect of chronic administration of ethyl p ‐chlorophenoxyisobutyrate (CPIB) on the secretion of bile lipids was studied in four dogs with surgically implanted Thomas cannulae for periods of 2–7 months. The concentration of cholesterol, triglycerides and p ‐chlorophenoxyisobutyric acid in serum and of bile acids, cholesterol and phospholipids (phosphatidyl cholines) in bile were measured. Chronic administration of CPIB resulted in a marked increase in the concentration of cholesterol, bile acids and phosphatidyl cholines in the bile of all dogs, and a decrease in serum cholesterol and triglyceride concentration in serum in three of the four dogs. Serum concentrations of p ‐chlorophenoxyisobutyric acid were monitored to insure the presence of the drug in the dogs; however, no correlation between serum levels of p ‐chlorophenoxyisobutyric acid and the concentration of biliary lipids was noted. The bile acids and p ‐chlorophenoxyisobutyric acid were determined by gas chromatographic procedures and the structures were confirmed by gas chromatography‐mass spectrometry.