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Dibutyryl cyclic adenosine 3′,5‐monophosphate and brain lipid metabolism
Author(s) -
Weiss Benjamin,
Stiller Richard L.
Publication year - 1974
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02532498
Subject(s) - adenosine , chemistry , lipidology , cyclic adenosine monophosphate , biochemistry , lipid metabolism , metabolism , serine , endocrinology , medicine , clinical chemistry , enzyme , biology , receptor
It was found that dibutyryl cyclic a denosine 3′,5′‐monophosphate exerted its greatest suppressive effect upon total lipid synthesis in 7–10 day old rat bran slices incubated in the presence of 2‐ 14 C‐acetate, U‐ 14 C‐D‐glucose, and 3‐ 14 C‐DL‐serine. Fractionation of the neutral and polar lipids disclosed that the formation of each of their respective components was reduced to varying extents, thus suggesting that cyclic adenosine 3′,5′‐monophosphate, arising from the hydrolysis of dibutyryl cyclic adenosine 3′,5′‐monophosphate, may control the synthesis of brain lipids by regulating the utilization of acetyl‐coenzyme A.