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Metabolism of linolenic acid in developing brain: I. Incorporation of radioactivity from 1‐ 14 C linolenic acid into brain fatty acids
Author(s) -
Dhopeshwarkar Govind A.,
Subramanian Carole
Publication year - 1975
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02532486
Subject(s) - linolenate , linolenic acid , lipidology , metabolism , clinical chemistry , chemistry , fatty acid , biochemistry , linoleic acid
Twelve‐thirteen day old rats were given 1‐ 14 C linolenic acid by intraperitoneal injection. Fatty acids were isolated from the brains of animals sacrificed at the end of 8 and 48 hr and 15 and 45 days. Eight hr after the tracer, radioactivity was found neither in 18∶3 nor its endproduct, 22∶6, and palmitate was the most highly radioactive component. At longer intervals, 22∶6 seemed to retain much of the radioactivity, whereas palmitate showed a precipitous decline in radioactivity. Initial oxidation of linolenate and sparing of the linolenate complexed with polar lipids are discussed.