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The incorporation of orally fed radioactive γ‐linolenic acid and linoleic acid into the liver and brain lipids of suckling rats
Author(s) -
Hassam A. G.,
Sinclair A. J.,
Cramwford M. A.
Publication year - 1975
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02532447
Subject(s) - lipidology , linoleic acid , clinical chemistry , arachidonic acid , chemistry , linolenic acid , in vivo , biochemistry , metabolism , medicine , fatty acid , endocrinology , biology , enzyme , microbiology and biotechnology
Abstract The incorporation of radioactivity from orally administered γ‐linolenic acid‐1‐ 14 C and linoleic acid‐ 3 H into the liver, plasma, and brain lipids of suckling rats was studied. Significantly more radioactivity from the former compound was incorporated into the liver and brain lipids 22 hr after dosing. The distribution of the radioactivity in the fatty acids of the liver and brain lipids was different for each isotope. Most of the 3 H was still associated with linoleic acid, whereas most of the 14 C was in the 20∶3 and 20∶4ω6 fractions. These results suggest that the desaturation of linoleic to γ‐linolenic acid in vivo is a rate‐limiting step in the conversion of linoleic to arachidonic acid.