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Lecithin: Cholesterol acyltransferase activity in hypercholesterolemic subjects and in hypercholesterolemic subjects treated with clofibrate
Author(s) -
D'Alessandro A.,
Zucconi A.,
Bellini F.,
Boncinelli L.,
Chiostri R.
Publication year - 1975
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02532324
Subject(s) - clofibrate , sterol o acyltransferase , lecithin , clinical chemistry , cholesterol , lipidology , medicine , chemistry , endocrinology , enzyme assay , enzyme , lecithin—cholesterol acyltransferase , biochemistry , lipoprotein
Abstract The lecithin: cholesterol acyl transfer reaction in the plasma of hypercholesterolemic subjects and of hypercholesterolemic subjects treated with clofibrate was studied. An increased enzyme activity was found in the first group of patients, while lecithin: cholesterol acyl transfer activity tended to normalize in the second group. This increased enzyme activity might be a defense mechanism against the accumulation of cholesterol in the arterial wall.