Premium
Cholesterol and bile acid turnover in miniature swine
Author(s) -
Dupont Jacqueline,
Oh SukYon,
O'Deen Louise,
McClellan Mary Anne,
Lumb William V.,
Butterfield Arthur B.,
Clow Duane J.
Publication year - 1974
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02532181
Subject(s) - cholesterol , clinical chemistry , bile acid , lipidology , lumen (anatomy) , medicine , enterohepatic circulation , aorta , vein , portal vein , chemistry , endocrinology , biology
Miniature swine were fitted with indwelling cannulae at two sites in the gut and catheters in the aorta and portal vein. Ring labeled cholesterol was administered via jejunum and portal vein and various parameters of disappearance measured over 17–66 days. Conversion of cholesterol to bile acids and their subsequent disappearance from gut lumen were measured. Cholesterol disappearance was found to follow a two component exponential in serum and three components in gut. The serum curves were similar to those reported for humans. It was concluded that the minipig is an advantageous model for cholesterol turnover studies and that serum and gut cholesterol dynamics are different.