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Effects of administration of hypolipidemic agent, 2,2′″‐[(1‐methyl‐4,4‐diphenylbutylidene)bis(p‐phenyleneoxy)] bistriethylamine oxalate (SQ 10,591) upon cholesterol esterification by aorta, adrenal, and testes of cholesterol‐fed rabbits
Author(s) -
Morin Robert J.
Publication year - 1975
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02532164
Subject(s) - medicine , endocrinology , cholesterol , microsome , oxalate , chemistry , aorta , clinical chemistry , lipidology , biochemistry , in vitro , biology , organic chemistry
Administration of 2,2′″‐([1‐methyl‐4,4‐diphenylbutylidene] bis(p‐phenyleneoxy]) bistriethylamine oxalate (SQ 10,591) at 20 mg/Kg daily for 5 days to cholesterol‐fed rabbits resulted in no change in aortic microsomal cholesterol esterification with a palmitoyl coenzyme A substrate or of aortic mitochondrial cholesterol esterification with a palmitate substrate. Esterification by both reactions in the adrenal was much higher than in either aorta or testes. Adrenal and testicular mitochondrial esterification and testicular microsomal esterification were inhibited significantly after SQ 10,591 administration. In vitro addition of 0.0001 M SQ 10,591 significantly inhibited both microsomal and mitochondrial cholesterol esterification in aorta, adrenal, and testes.