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Tumor lipids: Long chain dienoic acid in sphingomyelin
Author(s) -
Wood Randall
Publication year - 1974
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02532154
Subject(s) - sphingomyelin , sphingolipid , lipidology , clinical chemistry , chemistry , biochemistry , neuraminic acid , ceramide , fatty acid , metabolism , sphingosine , biology , cholesterol , sialic acid , apoptosis , receptor
Abstract The fatty acids derived from sphingomyelin fractions of 10 rat and mouse tumors were examined quantitatively. All tumors, except a nontransplantable fibroadenoma, contained significant levels of a C‐24 dienoic acid which is absent from sphingomyelin of normal tissues or present in only trace amounts. The data suggest an abnormality in the metabolism of sphingolipids of tumor cells.