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Inhibition of phospholipase C by isosteric phosphinic acid analogues of lecithin
Author(s) -
Rosenthal Arthur F.,
Chodsky Sergei V.
Publication year - 1974
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02532129
Subject(s) - phosphinate , phosphonate , chemistry , lecithin , stereochemistry , biochemistry , phospholipase c , inhibitory postsynaptic potential , phospholipase , enzyme , organic chemistry , biology , fire retardant , neuroscience
Four synthetic diether phosphinate analogues of lecithin were studied for inhibitory activity against Clostridium perfringens phospholipase C. An order of inhibitory effectiveness of phosphonate and phosphinate was, thereby, developed. The inhibitions seem relatively independent of specific structural features; this is discussed with emphasis on physical effects which complicate the inhibition kinetics.