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Effect of phospholipase a upon brain cholesterol ester formation
Author(s) -
Ramsey Robert B.,
Davison A. N.
Publication year - 1974
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02532062
Subject(s) - clinical chemistry , fatty acid , cholesteryl ester , phospholipase , chemistry , biochemistry , lipidology , fatty acid ester , phospholipase a2 , incubation , phospholipase c , phospholipase a , ethyl ester , enzyme , cholesterol , organic chemistry , lipoprotein
On addition of snake venom phospholipase A to homogenates of rat brain we have been able to show increased ester formation. Within certain limits, the amount of ester formed was dependent upon the amount of phospholipase added. The fatty acid patterns of free fatty acid released and of cholesteryl ester fatty acid formed during 18 hr incubation were compared. Although fatty acid patterns were different, the data were still consistent with the hypothesis that, in demyelination, a neural phospholipase A may play a role in cholesteryl ester deposition.