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Isolation of a trimer of α‐tocopherol from mammalian liver
Author(s) -
Draper H. H.,
Csallany A. S.,
Chiu Mei
Publication year - 1967
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02532000
Subject(s) - trimer , metabolite , tocopherol , chemistry , vitamin e , radical , antioxidant , lipidology , biochemistry , clinical chemistry , stereochemistry , quinone , in vivo , organic chemistry , biology , dimer , microbiology and biotechnology
Abstract Evidence is presented for the formation in mammalian liver of a trimeric metabolite of α‐tocopherol. This compound has been shown to be identical to a trimer produced by oxidation of α‐tocopherol with alkaline K 3 Fe(CN) 6 . In addition, confirmation was obtained for the occurrence in vivo of a dimeric metabolite reported previously. These compounds, together with tocopheryl‐ p ‐quinone, are postulated to arise from reactions with lipid‐free radicals or peroxides in the course of the antioxidant action of vitamin E.