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Agents affecting lipid metabolism. XXVI. Specificity of some inhibitors of the late stages of cholesterol biosynthesis
Author(s) -
Kraml M.,
Dubuc J.,
Dvornik D.
Publication year - 1967
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02531992
Subject(s) - desmosterol , reductase , biosynthesis , lipidology , sterol , cholesterol , clinical chemistry , biochemistry , enzyme , in vitro , metabolism , cholesterol synthesis , hmg coa reductase , hydroxymethylglutaryl coa reductase , chemistry , biology
The capacity of 22,25‐DAC, AY‐9944 and triparanol to inhibit cholesterol biosynthesis from three precursors, mevalonate, 7‐dehydrocholesterol and desmosterol, has been studied in rat liver homogenates. Evidence is presented that, in vitro, 22,25‐DAC, a potent inhibitor of the sterol Δ 24 ‐reductase, also inhibits the 7‐dehydrocholesterol‐Δ 7 ‐reductase system.