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Effect of biliary obstruction on canine plasma and biliary lipids
Author(s) -
Quarfordt S. H.,
Oelschlaeger H.,
Krigbaum W. R.,
Jakoi L.,
Davis R.
Publication year - 1973
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02531988
Subject(s) - lecithin , phospholipid , medicine , biliary tract , cholesterol , gastroenterology , lipidology , chemistry , endocrinology , biochemistry , membrane
The common bile duct was obstructed in 17 dogs. Reciprocal changes were noted for the plasma and biliary lipid concentrations of each after obstruction. As the plasma lecithin and free cholesterol concentrations increased, the biliary lipid concentrations declined. After biliary obstruction the reflux of biliary lecithin into the plasma of these animals was demonstrated with both labeled and unlabeled lecithin. The plasma lipid abnormalities seen after acute biliary obstruction were closely simulated by the reflux of lecithin alone from the biliary tree. The isolated reflux of biliary tract taurocholate produced a distinct lowering of plasma phospholipid and cholesterol concentrations, quite different from the plasma lipid alteration noted with acute biliary obstruction. Similar to observations in human obstruction, some of the plasma lipid was in mesophase form after these animals were obstructed.