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Hydroxystearic acid deposition and metabolism in rats fed hydrogenated castor oil
Author(s) -
Binder R. G.,
Booth A. N.,
Robbins D. J.,
Fuller G.
Publication year - 1970
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02531976
Subject(s) - castor oil , chemistry , lipidology , adipose tissue , food science , fatty acid , corn oil , clinical chemistry , biochemistry , organic chemistry
Groups of rats were fed diets containing corn oil, 1% hydrogenated castor oil (principal constituent: 12‐hydroxystearic acid) or 10% hydrogenated castor oil. Rats were sacrificed after 4, 8, 12 and 16 weeks for determination of hydroxy fatty acids in excised abdominal adipose tissue or in lipid extracted from lyophilized carcass. Maximum content of hydroxystearic acid was 4.4% in adipose tissue of rats four weeks on the 10% hydrogenated castor oil diet. When rats on hydrogenated castor oil diets were switched to the corn oil diet, hydroxystearic acid was depleted from their tissues. 10‐Hydroxypalmitic and 9‐hydroxymyristic acids were characterized as metabolites of 12‐hydroxystearic acid. No adverse effects of diets were observed except reduced growth in rats given 10% hydrogenated castor oil diet.