Premium
Effect of dietary cholesterol and fasting on hepatic 3‐hydroxy‐3‐methyl glutaryl coenzyme a hydrolase
Author(s) -
Saleemuddin M.,
Siddiqi Majid
Publication year - 1972
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02531969
Subject(s) - cycloheximide , medicine , endocrinology , clinical chemistry , cholesterol , hydrolase , cholesterol synthesis , enzyme , lipidology , coenzyme a , chemistry , hmg coa reductase , lovastatin , biology , biochemistry , reductase , protein biosynthesis
Hepatic HMG‐CoA hydrolase activity has been shown to increase in rats fasted for 72 hr or fed for 14 days on 5% cholesterol supplemented diet. Cycloheximide treatment resulted in further activation of this enzyme in animals fed cholesterol. Significant activation of HMG‐CoA hydrolase was also observed in rats fed normally and treated with cycloheximide and actinomycin D either individually or simultaneously.