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Enterohepatic circulation of cholic acid and cholesterol metabolism in the rat
Author(s) -
PericGolia Ludvik
Publication year - 1969
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02531934
Subject(s) - cholic acid , enterohepatic circulation , cholesterol , bile acid , medicine , endocrinology , chemistry , chenodeoxycholic acid , metabolism , taurocholic acid
A role for cholic acid in the regulation of body cholesterol levels is emphasized by the following experiment and findings. Fifteen rats with biliary and duodenal fistulae were divided into three groups. 4‐ 14 C‐cholesterol was admistered intravenously to all animals on day 1. Two groups received a duodenal infusion of either sodium taurocholate or of cholesterol at the same time and thereafter daily. Bile samples were collected daily for 15 consecutive days. Cholic, chenode‐oxycholic acid and cholesterol were the major labeled compounds in the bile. Labeled cholic acid disappeared from the bile of control animals after day 8 while it persisted in the group receiving unlabeled cholic acid up to day 15. The decrease of specific radioactivity of labeled biliary cholic acid in the rats receiving unlabeled cholesterol corresponded to that of control animals. A significant increase in the concentration of cholesterol was found in the plasma of animals receiving cholic acid and in the liver of those receiving unlabeled cholesterol.