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Probable sources of plasma cholesterol during phosphatide induced hypercholesterolemia
Author(s) -
Byers Sanford O.,
Friedman Meyer
Publication year - 1969
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02531930
Subject(s) - cholesterol , lecithin , medicine , endocrinology , chemistry , clinical chemistry , lipidology , specific activity , biology , biochemistry , enzyme
Rats in isotopic steady state with respect to 4‐ 14 C‐cholesterol were infused intravenously with massive amounts of lecithin and also injected once with Na acetate 3 H. During the following 8 hr their plasma gained an average of 11.3 mg of cholesterol; the specific activity of 14 C‐cholesterol fell in plasma while total 14 C‐cholesterol and 3 H activity doubled as compared to controls. The specific activity of 14 C‐cholesterol diminished in livers of rats receiving lecithin but not in controls. Specific activity of either isotope in cholesterol of intestine, lungs, muscle, skin and brains was the same in control and experimental groups. Total activity of 14 C and 3 H fell in cholesterol of liver. The results show that plasma accumulation of cholesterol during lecithin infusion derives from both cholesterol pre‐existing prior to infusion and from that newly synthesized after the start of infusion and that about one third of this cholesterol of mixed origin is supplied from the liver. The authors speculatively suggest skin as a likely source for most of the remainder, with a small additional contribution from brain.