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Absorption and biliary secretion of intraperitoneally injected 3β‐methoxycholest‐5‐ene‐4‐ 14 C in the rat
Author(s) -
Norcia L. N.
Publication year - 1973
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02531911
Subject(s) - cholic acid , chemistry , medicine , secretion , clinical chemistry , endocrinology , chenodeoxycholic acid , bile duct , cholesterol , absorption (acoustics) , chromatography , biochemistry , biology , physics , acoustics
Following ip injection of 1 mg amounts of methoxycholestene‐4‐ 14 C into normal intact rats, the amount of label in the whole liver was measured at different time intervals in different animals. These studies indicated that most of the injected compound was absorbed by or before 12 hr. In bile duct‐cannulated rats the secretion of label from ip injected methoxycholestene‐4‐ 14 C or cholesterol‐4‐ 14 C into bile was usually less during the first 24 hr than during the second 24 hr after injection. Studies on the nature of the labeled compounds in the bile following ip injection of methoxycholestene‐4‐ 14 C indicate that most of the label is present in metabolites, 47% of the label in cholic acid and 31% in chenodeoxycholic acid.