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Mass spectra of prostaglandins: II. Trimethylsilyl and alkyloxime‐trimethylsilyl derivatives of prostaglandins B 1 and B 2
Author(s) -
Middleditch B. S.,
Desiderio D. M.
Publication year - 1973
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02531903
Subject(s) - trimethylsilyl , chemistry , alkoxy group , oxime , ether , medicinal chemistry , moiety , mass spectrum , stereochemistry , organic chemistry , ion , alkyl
The mass spectra of the trimethylsilyl ester trimethylsilyl ether derivatives of prostaglandins B 1 and B 2 , and of their O ‐ethyl and O ‐methyl oximes are reported and discussed. The high resolution spectra of these compounds are also considered. These spectra are compared with those of the corresponding d 9 ‐trimethylsilyl derivatives and of the selectively labeled trimethylsilyl ester d 9 ‐trimethylsilyl ethers. The base peaks of the spectra of the trimethylsilyl derivatives are formed by sequential loss of C 5 H 11 (by cleavage of C‐15/6) and of CO (from the ring). The spectra of the oxime‐trimethylsilyl derivatives are dominated by ions resulting from loss of the alkoxy group of the oxime moiety.