Metabolism of 14 C‐labelled oleic acid, erucic acid and nervonic acid in rats
Author(s) -
Carroll K. K.
Publication year - 1966
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02531868
Subject(s) - erucic acid , lipidology , clinical chemistry , oleic acid , metabolism , chemistry , biochemistry , fatty acid , chromatography
Abstract 1‐ 14 C‐Oleic acid, 2‐ 14 C‐erucic acid and 2‐ 14 C‐nervonic acid were administered to rats by tail‐vein and the distribution of radioactivity in liver lipids was determined at intervals from 15 min to 6 hr after injection. High levels of activity were found after short time intervals which were mainly associated with triglycerides in the case of oleic acid and with free fatty acids in the case of erucic acid and nervonic acid. The activity in these lipids decreased with time and was later exceeded by that in more polar lipids. In rats given erucic acid or nervonic acid, sphingolipids were more highly labelled than glycerophosphatides. Nervonic acid showed little tendency to form a complex with serum albumin and erucic acid complexed less readily than palmitic acid.