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Effects of ethanol on membrane lipids III. Quantitative changes in lipid and fatty acid composition of nonpolar and polar lipids of mouse total liver, mitochondria and microsomes following ethanol feeding
Author(s) -
Miceli Joseph N.,
Ferrell William J.
Publication year - 1973
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02531839
Subject(s) - polyunsaturated fatty acid , chemistry , biochemistry , lipidology , ethanol , microsome , clinical chemistry , docosahexaenoic acid , arachidonic acid , fatty acid , membrane lipids , lipid metabolism , mitochondrion , phospholipid , diacylglycerol kinase , membrane , enzyme , protein kinase c
The effects of ethanol on the total, nonpolar, and polar lipids of whole liver, mitochondria, and microsomes have been evaluated. Differences in the fatty acid composition of various lipid subclasses have been compared in control and ethanol treated mice. On the whole polyunsaturated fatty acids, especially arachidonic (20∶4) and docosahexaenoic (22∶6), were found to decrease. The significance of an enzymatic mechanism vs. a peroxidative mechanism to explain the results is discussed. Decreases also were observed in the ratios of arachidonate/linoleate following ethanol feeding. These changes are thought to be associated with decreases in the activity of the chain elongation‐desaturation system.