z-logo
Premium
Differential effects of benzodioxane, chroman and dihydrobenzofuran analogs of clofibrate in a triton hyperlipemic rat model
Author(s) -
Newman Howard A. I.,
Hellman William P.,
Witiak Donald T.
Publication year - 1973
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02531712
Subject(s) - clofibrate , chemistry , propionates , carboxylic acid , clofibric acid , propionate , stereochemistry , biological activity , carboxylate , organic chemistry , biochemistry , in vitro
Clofibrate (ethyl 2‐methyl‐2‐[4‐chlorophenoxy] propionate) is currently an important hypolipemic agent. In this study we describe the biological properties of certain acyclic and cyclic analogs of clofibrate in a hyperlipemic rat model in which the hyperlipemia was induced by ip injection of Triton WR‐1339. Cyclic analogs studied for their hypocholesterolemic and hypotriglyceridemic activities, as well as their ability to modify lipoprotein patterns, include the ethyl esters of 1,4‐benzodioxane‐2‐carboxylic acid, 6‐chlorochroman‐2‐carboxylic acid and 5‐chloro‐2,3‐dihydrobenzofuran‐2‐carboxylic acid. Among the clofibrate analogs, ethyl 6‐chlorochroman‐2‐carboxylate compares most favorably with the parent compound. Whereas the 6‐chlorochroman‐2‐carboxylate is effective as a hypocholesterolemic and hypotriglyceridemic agent, the 1,4‐benzodioxane analog exhibits mainly hypotriglyceridemic activity, while the 2,3‐dihydrobenzofuran analog exhibits hypocholesterolemic activity. Except for the benzodioxane, deschloro analogs are inactive. Results obtained in these studies are discussed in terms of structural requirements for biological activity and modes of action proposed for the parent drug clofibrate.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here