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The turnover time of dietary cholesterol in the lactating rat
Author(s) -
Easter D. J.
Publication year - 1971
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02531522
Subject(s) - lipidology , clinical chemistry , cholesterol , globules of fat , milk fat , endocrinology , intracellular , medicine , chemistry , secretion , mammary gland , membrane , biology , biochemistry , food science , cancer , breast cancer , linseed oil
The secretion of dietary 4‐ 14 C‐cholesterol into milk of the rat was determined as a function of post‐feeding time by a single dose technique. The time interval which elapsed before maximum specific radioactivity was reached in milk (17–20 hr after maximum activity in the serum) suggests a route through the mammary gland involving transport of the cholesterol by intracellular membranes. It also suggests that the exogenous cholesterol is incorporated into the milk fat globule membranes rather than into the fat globules during their synthesis within the cell.