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On the rate of cholesterol esterification in cord blood serum
Author(s) -
Lacko Andras G.,
Rutenberg Harold L.,
Soloff Louis A.
Publication year - 1972
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02531515
Subject(s) - clinical chemistry , cholesterol , lecithin—cholesterol acyltransferase , lecithin , medicine , lipidology , chemistry , cord blood , endocrinology , sterol o acyltransferase , biochemistry , biology , lipoprotein
Cholesterol esterification was studied in adult and cord serum by measureing the initial rate of lecithin‐cholesterol acyl transferase (LCAT) activity. Cord serum had about one‐third as much free and esterified cholesterol and about one‐half as much LCAT as adult serum. When the adult LCAT activities are plotted against the individual's serum free cholesterol levels a straight line relationship results (0.101±.005% cholesterol esterified per min). Cord serum LCAT activities (.135±.0407% cholesterol esterified per min) in the main fall above the adult line. Our results show that cord serum can esterify cholesterol at a rate equal to or higher than adult serum when the LCAT activity is related to the amount of serum free cholesterol present.