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The effect of hydrogen peroxide on serum lecithin‐cholesterol acytransferase activity
Author(s) -
Mickel Hubert S.,
Foulds Emmett L.
Publication year - 1970
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02531347
Subject(s) - chemistry , lecithin , clinical chemistry , hydrogen peroxide , sterol o acyltransferase , cholesterol , lipidology , peroxide , cholesteryl ester , biochemistry , enzyme , chromatography , organic chemistry , lipoprotein
Glomset has reported an acyltransferase in plasma which effects the transfer of a fatty acid from the beta position of lecithin to cholesterol, forming cholesteryl esters. Peroxide is shown to have an inhibitory effect on the enzyme activity in a concentration of 0.1 M. There is a variable effect with a concentration of 0.01 M, with a stimulation of activity in some sera, while in others an inhibition. The addition of a synthetic saturated lecithin does not cause a reversal of the inhibition at 0.1 M H 2 O 2 .
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