Inhibition of renal cortical Rb +  transport by phospholipase C and its relationship to (Na + +K + )‐adenosine triphosphatase | Zendy

Malila Amra | Zendy; Masoro Edward J. | Zendy

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Inhibition of renal cortical Rb + transport by phospholipase C and its relationship to (Na + +K + )‐adenosine triphosphatase

Author(s) -

Malila Amra,

Masoro Edward J.

Publication year - 1970

Publication title -

lipids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.601

H-Index - 120

eISSN - 1558-9307

pISSN - 0024-4201

DOI - 10.1007/bf02531345

Subject(s) - triphosphatase , adenosine triphosphatase , phospholipid , phospholipase c , adenosine , enzyme , phospholipase , chemistry , biochemistry , biophysics , biology , membrane , atpase

Treatment of isolated renal cortical tubules with a low concentration of phospholipase C (one which does not lead to a chemically detectable loss of tubular phospholipid) results in a markedly inhibited Rb + transport function which is referable to the loss of a phospholipid component of the tubules. This treatment also results in an inhibition of the (Na + +K + )‐adenosine triphosphatase enzyme of the tubules. The data are consistent with the concept that it is the loss in (Na + +K + )‐adenosine triphosphatase activity which is responsible for phospholipase C‐induced inhibition of Rb + transport.

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