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Inhibition of renal cortical Rb + transport by phospholipase C and its relationship to (Na + +K + )‐adenosine triphosphatase
Author(s) -
Malila Amra,
Masoro Edward J.
Publication year - 1970
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02531345
Subject(s) - triphosphatase , adenosine triphosphatase , phospholipid , phospholipase c , adenosine , enzyme , phospholipase , chemistry , biochemistry , biophysics , biology , membrane , atpase
Treatment of isolated renal cortical tubules with a low concentration of phospholipase C (one which does not lead to a chemically detectable loss of tubular phospholipid) results in a markedly inhibited Rb + transport function which is referable to the loss of a phospholipid component of the tubules. This treatment also results in an inhibition of the (Na + +K + )‐adenosine triphosphatase enzyme of the tubules. The data are consistent with the concept that it is the loss in (Na + +K + )‐adenosine triphosphatase activity which is responsible for phospholipase C‐induced inhibition of Rb + transport.