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Fatty acid metabolism in Drosophila melanogaster : II. Metabolic origin of monoenes
Author(s) -
Kiyomoto R. K.,
Keith A. D.
Publication year - 1970
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02531340
Subject(s) - metabolism , drosophila melanogaster , chemistry , fatty acid , biochemistry , clinical chemistry , metabolic pathway , biosynthesis , lipidology , carbon chain , stereochemistry , organic chemistry , enzyme , gene
Evidence is presented that Drosophila larvae produce monounsaturated fatty acids by two independent pathways. One of these pathways, involving the direct desaturation of long chain precursors, is sensitive to inhibition by linoleate. The other pathway is resistant to linoleate inhibition and probably has tetradecnoate‐Δ 5 cis and tetradecnoate‐Δ 7 cis as intermediates in the synthesis of palmitoleate and oleate, respectively. The use of radioactive precursors of varying chain length and labeled at different positions in the carbon chains provided evidence for the isolation and structure of intermediates involved in the linoleate resistant pathway.