Premium
Potential function of cholesterol in blood coagulation: Amplification of phospholipid thromboplastic activity
Author(s) -
Sorbye Oyvind,
Phillips Fred C.,
Lundberg W. O.
Publication year - 1971
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02531330
Subject(s) - lipidology , cholesterol , phospholipid , coagulation , viper venoms , chemistry , clinical chemistry , biochemistry , medicine , snake venom , venom , membrane
Recalcification tests have revealed a two‐ to threefold increase in the thromboplastic activity of recombined phospholipid fractions from chicken erythrocyte lipids on supplementation with the original concentration of cholesterol. An optimal four‐ to fivefold increase was obtained at higher levels. Cholesterol esters had no such effect and clotting times with Russell's viper venom were not similarly affected.