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Some pathways and mechanisms in lanosterol‐cholesterol conversion in mammalian tissues
Author(s) -
Paoletti R.,
Galli G.,
Paoletti E. Grossi,
Fiecchi A.,
Scala A.
Publication year - 1971
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02531329
Subject(s) - lanosterol , double bond , sterol , cholesterol , desmosterol , biochemistry , clinical chemistry , chemistry , mevalonate pathway , lipidology , stereochemistry , biology , biosynthesis , organic chemistry , enzyme
Sterol precursors of cholesterol with a double bond in the lateral chain are present in normal human brain and glioblastoma. Biosynthetic experiments with labeled mevalonate show that the unsaturated intermediates are preferentially labeled when compared with the corresponding saturated sterols. The biological role of sterols containing an 8(14) double bond is discussed.