Premium
The comparative oxidation of palmitic, oleic and succinic acids by rat and bat brown adipose tissue homogenates as a function of temperature
Author(s) -
Dryer Robert L.,
Paulsrud John R.,
Brown Donald J.,
Mavis Karol
Publication year - 1970
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02531088
Subject(s) - brown adipose tissue , thermogenesis , biology , hibernation (computing) , biochemistry , palmitic acid , oleic acid , chemistry , adipose tissue , fatty acid , state (computer science) , algorithm , computer science
Abstract The oxidation of 1‐ 14 C‐palmitic, 1‐ 14 C‐oleic and 2‐ 14 C‐succinic acids to 14 CO 2 by homogenates of brown adipose tissue (BAT) from rat and bat was studied as a function of temperature. In all cases bat BAT gave a greater conversion of added fatty acids to 14 CO 2 than did rat BAT. The conversion of labeled succinate to 14 CO 2 is greater in the bat than in the rat only at low temperatures. In all paired observations below 30 C the energy of activation (E A ) of the bat preparations are lower than the rat. This indicates a greater thermal efficiency for the oxidation of the indicated substrates. The bat BAT homogenates show a greater efficiency than rat homogenates in the amount of succinate oxidation associated with the oxidation of long chain fatty acids to CO 2 . The significance of these findings to thermogenesis by BAT in hibernation and cold adaptation is discussed.