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Reciprocal interactions in the desaturation of linoleic acid into γ‐linolenic and eicosa‐8,11,14‐trienoic into arachidonic
Author(s) -
Brenner R. R.
Publication year - 1969
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02531052
Subject(s) - arachidonic acid , lipidology , linoleic acid , clinical chemistry , chemistry , microsome , biochemistry , fatty acid , cofactor , enzyme
Variable concentrations of [I 14 C] linoleic acid and [I 14 C] eicosa‐8,11,14‐trienoic acid were incubated with liver microsomes in a medium containing the necessary cofactors for fatty acid desaturation. The conversion of linoleic into γ‐linolenic acid and eicosatrienoic into arachidonic acid were mutually inhibited and the inhibition depended on the concentration of the fatty acids incubated.