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The total synthesis and metabolism of 4‐decenoate, dodeca‐3,6‐dienoate, tetradeca‐5,8‐dienoate and hexadeca‐7,10‐dienoate in the fat‐deficient rat
Author(s) -
Sprecher Howard
Publication year - 1968
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02530962
Subject(s) - chemistry , metabolism , clinical chemistry , lipidology , gas chromatography , stereochemistry , organic chemistry , biochemistry , chromatography
Abstract Methyl 4‐decenoate (10∶1ω6), methyl dodeca‐3,6‐dienoate (12∶2ω6), methyl tetradeca‐5,8‐dienoate (14∶2ω6) and methyl hexadeca‐7,10‐dienoate (16∶2ω6) were prepared by total synthesis. Rats raised on a fat‐deficient diet for 2 1/2 months received 100 mg per day of one of the experimental acids or methyl linoleate for a period of 16 days. The liver lipids were extracted, converted to methyl esters and analyzed by gas‐liquid chromatography. Neither 10∶1ω6 nor 12∶2ω6 served as biosynthetic precursors for linoleate. Small amounts of 14∶2ω6 were convered to linoleate while 16∶2ω6 served as an efficient precursor for linoleate and longer chain ω6 acids. None of the short chain ω6 acids were incorporated directly into liver lipids.