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Metabolism of chimyl alcohol and phosphatidyl ethanolamine in the rat brain
Author(s) -
Bickerstaffe Roy,
Mead James F.
Publication year - 1968
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02530931
Subject(s) - ethanolamine , phosphatidylethanolamine , chemistry , alcohol , ethanolamines , metabolism , fatty alcohol , organic chemistry , clinical chemistry , lipidology , biochemistry , phospholipid , phosphatidylcholine , membrane
Following intracerebral injection of 14 C‐phosphatidylethanolamine and 3 H‐chimyl alcohol into 18 day old rats, the ethanolamine phosphoglycerides were isolated and analyzed. The 14 C and 3 H activities in the dimethyl acetals derived from alkenyl acyl ethanolamine phosphoglycerides and in the glyceryl ethers derived from the alkyl acyl ethanolamine phosphoglycerides were measured. The absence of 14 C in the dimethyl acetals indicates that phosphatidyl ethanolamine is not transformed into phosphatidal ethanolamine under these circumstances. The increase with time of the 3 H content of the glyceryl ethers and dimethyl acetals indicates that chimyl alcohol was a precursor of both types of phospholipids.